[Nature Nanotechnology]Lipid Multilayer gratings

论文来源

Nature Nanotechnology

供稿人

蔡涛

作者简介（作者名称、学历、职称、国籍、研究院或学校名称、作者研究方向等）

Joris Roels

even Lenhert^1,2,3*, Falko Brinkmann^1,2, Thomas Laue¹, Stefan Walheim^1,4, Christoph Vannahme⁵,

Soenke Klinkhammer⁶, Miao Xu¹, Sylwia Sekula¹, Timo Mappes⁵, Thomas Schimmel^1,4

and Harald Fuchs^1,2,7

¹Institute of Nanotechnology, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany, ²Physikalisches Institut, Westfalische Wilhelms-Universitat, and Center for Nanotechnology (CeNTech), 48149 Munster, Germany,

³Department of Biological Science and Integrative NanoScience Institute, Florida State University, Tallahassee, Florida 32306-4370, USA,

⁴Institute of Applied Physics, Center for Functional Nanostructures (CFN), Karlsruhe Institute of

Technology, 76128 Karlsruhe, Germany,

⁵Institut fur Mikrostrukturtechnik, Karlsruhe Institute of Technology, 76128 Karlsruhe, Germany, ⁶Light Technology Institute, and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology, 76128 Karlsruhe, Germany,

⁷Department of Nanobio Materials and Electronics, Gwangju Institute of Science and Technology, Gwangju, Korea.

*e-mail: lenhert@bio.fsu.edu

论文内容与特点简介：

篇名：Lipid Multilayer gratings 刊名：Nature Nanotechnology    ISSN: 1748-3387

卷期：5卷   出版日期：2010年4月   页码：275-279        DOI：10.1038/NNANO.2010.17

摘要：

The interaction of electromagnetic waves with matter can be controlled by structuring the matter on the scale of the wavelength of light, and various photonic components have been made by structuring materials using top-down or bottom-up approaches^1–5. Dip-pen nanolithography is a scanning-probe based fabrication technique that can be used to deposit materials on surfaces with high resolution and, when carried out in parallel, with high throughput^6–8. Here, we show that lyotropic optical diffraction gratings—composed of biofunctional lipid multilayers with controllable heights between ~5 and 100 nm—can be fabricated by lipid dip-pen nanolithography. Multiple materials can be simultaneously written into arbitrary patterns on pre-structured surfaces to generate complex structures and devices, allowing nanostructures to be interfaced by

combinations of top-down and bottom-up fabrication methods. We also show that fluid and biocompatible lipid multilayer gratings allow label-free and specific detection of lipid–protein

interactions in solution. This biosensing capability takes advantage of the adhesion properties of the phospholipid superstructures and the changes in the size and shape of the grating elements that take place in response to analyte binding.