激光生物医学研究所
Institute of Laser Biomedicine
激光生物医学研究所旨在发展和利用先进的激光技术，解决现代生物医学与环境监测等领域的应用需求，发展先进生物医学与环境监测光学仪器。该领域属于国际前沿的交叉研究领域，通过整合协调多方向的专业人才，形成有机整体。激光技术及应用瞄准交叉领域的应用需求，发展激光与新光源技术，特别是高功率脉冲光纤激光器和中波红外激光器；生物医学光学成像和环境监测基于新光源技术开展新方法与系统研究，为生物医学应用服务；生物医学图像分析则基于获取的各种医学图像进行深入的信息获取研究。本研究所获得973、863、国家自然科学重点基金、杰出青年基金等国家级课题的持续资助，曾获得浙江省科学技术奖二等奖1项，浙江省教学成果奖1项，负责制订了国际标准IEC62341-6-3，IEC 62471-4。研究所已培养硕士、博士研究生遍布世界各地，并致力于成为激光生物医学领域知名研究团队与人才培养基地。
研究所现有教授7
，副教授3
，讲师2
。拥有22-Na放射性点源、超连续谱激光光源、高速扫频激光器、多台光电倍增管和相应的后端分析设备、红外脑电波探测仪、安捷伦阻抗分析仪等系列设备，自行研发的先进激光光源与各种生物医学应用自制仪器。
主要研究方向：
新型探测技术与PET系统，图像处理与生理参数分析；
结构与功能OCT技术与应用，无标记光学微血管造影技术与应用，多光子成像方法和定量表征；
深穿透光学显微和光学聚焦，脑信息的光学读取和调控。
联系我们：
所长：丁志华 Director：Zhihua Ding,
Tel：0571-87951194, E-mail：zh_ding@zju.edu.cn
党支部书记兼副所长：刘华锋Associate Director：Huafeng Liu,
Tel：0571-87951674, Email: liuhf@zju.edu.cn
副所长：斯科Associate Director：Ke Si,
Tel：0571-87951187, Email: kesi@zju.edu.cn
Institute of Laser Biomedicine
The Institute of Laser Biomedicine aims to the promotion of optical instrumentation in modern biomedicine and environmental monitoring by the development or the usage of advanced laser technology. An integrated research group from professionals with diverse backgrounds is formed at this interdisciplinary field. Advanced Laser technologies focus on the development of Laser technology and other novel light sources, especially high-power fiber lasers and mid-infrared lasers. Optical imaging and environmental monitoring dedicate to novel method and instrumentation for biomedical applications. Image processing and analysis is to extract clinical relevant information for early detection and diagnosis. Continuous financial supports including national 973 project, national 863 project, and National Natural Science Foundation have been granted. Awards of the Second Prize of Zhejiang Science and Technology and the Teaching Achievement Prize of Zhejiang Province have been received. International standards IEC62341-6-3 and IEC 62471-4 are formulated under the responsibility of the professor from our institute. The Institute of Laser Biomedicine is dedicated to be an internationally renowned research team and a training base for Master and PhD candidates in the area of Laser biomedicine.
Currently, there are 7 professors, 3 associate professors and 2 lectures in the institute. Commercial equipment including 22-Na point source, supercontinuum laser source, high-speed swept source, PMTs, infrared brain waves detector, impedance analyzer and several home-established lasers and systems for biomedical applications are available.
Main research areas:
High power pulsed fiber laser, Mid-infrared laser, Ultra-fast fiber laser technique
The structural and functional OCT technology and applications, Label-free optical microangiography technology and application, Multi-photon microscopy and quantitative characterization
Novel detector and PET system, Biomedical image processing and analysis
Deep-penetration optical microscopy and focusing, Brain information by optical acquisition and operation
主要成果 (Major Achievements):
图1. OCT探头、系统及结构与功能成像
Figure 1. OCT probe, system, structural and functional imaging.
图2.基于深度学习，能够从磁共振图像序列中有效地识别出心肌梗死区块。
Figure 2. Deep learning assessment of myocardial infarction from MR image sequences.
图3.基于迭代声光作用，在组织深层显微成像中突破空间分辨率屏障。
Figure 3. Breaking the spatial resolution barrier via iterative sound-light interaction in deep tissue microscopy.
图4.基于掺镱光纤激光泵浦的光参量放大器，产生宽带高功率中红外飞秒光脉冲。
Figure 4. Broadband high-power mid-IR femtosecond pulse generation from an ytterbium-doped fiber laser pumped optical parametric amplifier.
图5.首次从实验上观测到孤子分子在锁模激光器中的完整积聚过程。
Figure 5. The first observation of the entire buildup process of soliton molecules (SMs) in a mode-locked laser.